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Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study

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In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

The reconstituted solution is reliably usable for approximately 24 hours after which, for research purposes, the solution should be discarded

BAC water is sterile water that contains 0.9% benzyl alcohol, a mild preservative